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Researcher Nakul, Manisha
Advisor Shukla, P. C.
Source KrishiKosh-Indian National Agricultural Research System
Content type Text
Educational Degree Master of Science (M.Sc.)
Publisher Nanaji Deshmukh Veterinary Science University Jabalpur
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Agriculture & related technologies ♦ Animal husbandry
Subject Keyword Canine Parvovirus ♦ The Haemato-biochemical ♦ Scientific Research ♦ Veterinary Medicine ♦ Applied Research
Abstract Canine parvovirus (CPV) infection is a highly contagious viral infection that can affects dogs of all ages. The disease is caused by Canine parvovirus-2 (CPV-2). There are two forms of CPV-2: intestinal and cardiac form. The more common form is intestinal form, which is characterized by frequent vomiting and diarrhoea which results in dehydration, weight loss and anorexia. On account of dehydration, the fluid and electrolyte balance of the dogs become critically affected. So, in view of the above facts the present work was framed to study the epidemiological pattern of Parvovirus infection in dogs in and around Jabalpur, to study the haemato-biochemical alterations in dogs suffering from Parvovirus infection and to find out the specific fluid therapy in Parvovirus infected dogs. A total of 1200 dogs between August 2012 to May 2013 brought to TVCC, Jabalpur and Government Veterinary hospital, Omti were examined. Amongst these, on clinical examination the dogs which showed gastroenteritis were screened by Scanvet Parvotm kit (Immunochromatographic assay based kit) for the diagnosis of CPV infection. To study the epidemiological pattern of CPV apart from various clinical signs age, sex, breed and feeding habits of the dogs positive for CPV infection were also recorded. For haemato-biochemical estimation 5 ml blood was collected from CPV infected dogs pre treatment (0 day) and day 7 and 14 post treatment including dogs of control group. To assess the specific fluid therapy, 36 dogs positive for Canine parvovirus infection were taken and divided into 6 groups with 6 dogs in each group. Besides these a group of 6 healthy dogs was kept as control group. The group T1 was treated with inj. Ringer’s lactate @ 10 ml/kg b.wt., BID, I/V for 5 days, the group T2 was treated with inj. Isolyte @ 10 ml/kg b.wt.. BID, I/V for 5 days, the group T3 was treated with inj, Normal saline @ 10 ml/kg b.wt., BID, I/V for 5 days, the group T4 was treated with inj. Hemaccel @ 5 ml/kg b.wt., SID, I/V for 5 days + inj. Ringer’s lactate @ 10 ml/kg b.wt., BID, I/V for 5 days, group T5 was treated with inj. Hemaccel @ 5 ml/kg b.wt., SID, I/V for 5 days + inj. Isolyte @ 10 ml/kg b.wt., BID, I/V for 5 days and group T6 was treated with inj. Hemaccel @ 5 ml/kg b.wt., SID, I/V for 5 days + inj. Normal Saline @ 10 ml/kg b.wt., BID, I/V for 5 days The overall prevalence of CPV infection was 7.08% (85 out of 1200 dogs). The age wise prevalence showed maximum between 0-3 months of age i.e. 11.25%, followed by 3-6 month of age (7.58%), 6-12 month of age (5.92%) and above 12 month of age it was 1.10%. Among 1200 dogs examined, the sex wise prevalence study revealed 7.76% prevalence in males as compared with 6.23% in females.The maximum breed wise prevalence was noticed in non-descript dogs i.e. 11.69% followed by Spitz, Daschund, Dalmatian, German shepherd, Labrador, Lhasa apso and Doberman i.e. 7.25%, 5.26%, 4.16%, 3.56%, 2.99%, 2.38% and 1.00% respectively. During the present study the dogs reared on vegetarian diet showed higher prevalence i.e. 9.79% as compared with 2.79% in dogs reared on non-vegetarian diet. The clinical symptoms exhibited as anorexia (84.70%), vomition (100%), paleness of mucous membrane (25.88%) and the haemorrhagic diarrhoea (89.41%) in all the cases under the study; however the increased body temperature was noted in 52.94% dogs. The degree of dehydration was varied as mild, moderate and severe in 23.53%, 49.41% and 27.06% dogs respectively under the present study. Regarding various haematological parameters the total erythrocyte count (millions/µl) and lymphocyte (%) were significantly lower (p≤0.01), with significantly higher (p≤0.01) packed cell volume (%) and neutrophil (%) than that of the healthy control group on the day 0 pre-treatment. However, no statistically significant changes were observed in Total leukocyte count (thousands/µl), haemoglobin concentration (g/dl), monocyte (%) and eosinophil (%). The results of biochemical parameters showed a statistically significant (p≤0.01) higher value of alanine transaminase (U/L), aspartare transminase (U/L), total bilirubin (mg/dl) and creatine kinase (U/L), while significantly lower (p≤0.01) value was noticed in glucose (mg/dl), total protein (g/dl), albumin (g/dl) and globulin (g/dl) with that of healthy group. The present study revealed that among the various treatment groups T5 (inj. Hemaccel + inj. Isolyte) was found to be superior as all the 6 dogs recovered from dehydration with appreciable health status by day 3 post treatment.
Educational Use Research
Education Level UG and PG
Learning Resource Type Thesis
Size (in Bytes) 706.88 kB
Page Count 67