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Researcher Prabha, Naveen
Advisor Kumar, Ashok
Source KrishiKosh-Indian National Agricultural Research System
Content type Text
Educational Degree Master of Science (M.Sc.)
Publisher LUVAS
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Agriculture & related technologies ♦ Animal husbandry
Subject Keyword Dogs ♦ Endoscopy ♦ Vincristine Sulphate ♦ Veterinary Surgery and Radiology ♦ Endoscopic Assessment of Upper Gastrointestinal Tract Following Vincristine Sulphate Administration In Dogs
Abstract The study was conducted on 10 clinically healthy adult dogs divided into two groups of five animals each to assess the effects of vincristine sulphate on upper gastrointestinal tract of dogs endoscopically and to know the effect of drug on various haematological and blood biochemical parameters. In group 1 and 2 vincristine sulphate was administered @ 0.016 and @ 0.025 mg/kg intravenously once a week for three weeks respectively. Endoscopy was performed before administration of vincristine sulphate and on every 5th day of drug administration. Blood samples were collected prior to every endoscopic procedure. All the dogs were monitored regularly for various clinical signs in both the groups, only one dog exhibited lethargy and anorexia at second dose of drug. In both the groups, none of the animal revealed any abnormal oesophagoscopy findings throughout the study. In group 1, on gastroscopy two animals had localized pin point haemorrhages and another two had increased granularity of mucosa of stomach at day 5. No abnormal lesions were found in any of the animals on gastroscopy performed at day 12 while, at day 19, on gastroscopy, three animals were having mild gastric lesions like localized pin point haemorrhages, and increased granularity of gastric mucosa at a place or two. In group 2, gastroscopy performed at day 5, revealed mild gastric lesions like increased granularity and localized pin point haemorrhages in two dogs. endoscopically, nothing abnormal on was detected in any dog of group 2 at day 12 and 19. In both the groups, a significant fall in MCH and non significant fall in TEC, TLC and increase in total platelets was seen. A non significant fall in Hb was seen in group 1 but it declined significantly in group 2. An increase in glucose levels from base value at day 5 and rise in ALP, ALT, GGT, LDH and CK from base value was seen in both groups. In group 2, there was a significant fall in A:G ratio at day 5 and 12 and significant rise in potassium at day 12. No significant changes were observed in any other parameters. On the basis of present study it was concluded that vincristine sulphate in dogs seems to cause mild injury on gastric mucosa which was dose independent.
Educational Use Research
Education Level UG and PG
Learning Resource Type Thesis
Size (in Bytes) 5.83 MB