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Researcher Prakruthi, B. S.
Advisor Suja, Rani S.
Source KrishiKosh-Indian National Agricultural Research System
Content type Text
Educational Degree Master of Science (M.Sc.)
Publisher Kerala Veterinary and animal science university
File Format PDF
Language English
Subject Domain (in DDC) Technology ♦ Agriculture & related technologies ♦ Animal husbandry
Subject Keyword Phyllanthus Emblica ♦ Herbs ♦ Anti-dyslipidemic Effect ♦ Veterinary Pharmacology and Toxicology ♦ Anti-dyslipidemic Effect In Albino Ratsâ€
Abstract The anti-dyslipidemic potential of different extracts of Phyllanthus emblica leaves was investigated in acute dyslipidemic rat model and the most potent extract amongst them was further evaluated for dose response in the chronic dyslipidemic rat model. All the extracts were qualitatively screened for the presence of various phyto-active principles, while the most potent extract selected among them was subjected to acute oral toxicity evaluation. Different extracts of P. emblica leaves such as petroleum ether, ethanolic, hydro ethanolic and aqueous extracts were initially screened for anti-dyslipidemic effect at a dose level of 200 mg/kg body weight in triton WR-1339 (200 mg/kg i.p.) induced acute dyslipidemia rat model and ethanolic extract of P. emblica leaves (EPEL) was found to be the most potent among them. The phytochemical screening of EPEL revealed the presence of alkaloids, tannins, flavonoids, glycosides, phenolic compounds, saponins and steroids, whereas some of these active principles were lacking in the other extracts. Later, EPEL was subjected to further antidyslipidemic evaluation at 50, 100 and 200 mg/kg body weight dose levels for a period of four weeks in cholesterol (500 mg/kg) and cholic acid (50 mg/kg) induced dyslipidemic rats. The treatment with EPEL significantly reversed the cholesterol and cholic acid induced abnormal serum and hepatic lipidemic parameters viz.TC, TG, high density lipoprotein cholesterol (HDL-c), Non-HDL-c, atherogenic index in a dose dependent manner. Body weight and relative organ weights did not show any significant changes among the different experimental groups, while the cholesterol and cholic acid induced rise in hepatic and renal toxicity markers such as alanine amino transferase (ALT), aspartate amino transferase (AST), blood urea nitrogen (BUN) and creatinine were restored by the EPEL treatment. Moreover, EPEL was found to be safe upto an acute oral dose level of 2000 mg/kg body weight as per OECD guidelines. Thus the findings of the present study indicated that ethanolic extract of P. emblica leaves is a safer anti-dyslipidemic agent which might be recommended for the effective management of dyslipidemia.
Educational Use Research
Education Level UG and PG
Learning Resource Type Thesis
Publisher Place Pookode
Size (in Bytes) 1.47 MB
Page Count 62