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Author Arley, N. ♦ Eker, R.
Sponsorship USDOE
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword BIOLOGY AND MEDICINE ♦ CARCINOGENESIS ♦ MUTATIONS ♦ RADIATION EFFECTS ♦ STATISTICS ♦ TOXICITY ♦ TUMORS
Abstract Data on dose-response relationship and threshold dose in radioinduced neoplasms are discussed. The author presents an analysis of statistical data which he interprets as indicating that the direct one-hit form of the somatic mutation hypothesis actually leads to a sufficiently flexible doseresponse curve which can be fitted with qualitative agreement to experimental values showing not only a linear form but also a sigmoid form and a form with a maximum. In some cases a threshold is simulated. Thus it is shown that radiation carcinogenesis does not show one and the same form of dose-response curve common to all casps, but the form varies from case to case, depending on the experimental conditions and the relative importance of the effects of toxicity, elimination, and adaptation in each specific case. (C.H.)
Educational Use Research
Learning Resource Type Article
Publisher Date 1961-01-14
Publisher Department Norsk Hydro's Inst. for Cancer Research, Norway
Journal Nature
Volume Number 189
Organization Norsk Hydro's Inst. for Cancer Research, Norway


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