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Author Haddadi, Siamak ♦ Xing, Zhou ♦ Lai, Rocky ♦ Afkhami, Sam ♦ Jeyanathan, Mangalakumari
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher European Respiratory Society
File Format HTM / HTML
Date Created 2015-06-03
Copyright Year ©2015
Language English
Subject Domain (in LCC) RC705-779
Subject Keyword Diseases of the respiratory system ♦ Internal medicine ♦ Medicine ♦ Specialties of internal medicine
Abstract Despite the use of bacille Calmette–Guérin (BCG) for almost a century, pulmonary tuberculosis (TB) continues to be a serious global health concern. Therefore, there has been a pressing need for the development of new booster vaccines to enhance existing BCG-induced immunity. Protection following mucosal intranasal immunisation with AdHu5Ag85A is associated with the localisation of antigen-specific T-cells to the lung airway. However, parenteral intramuscular immunisation is unable to provide protection despite the apparent presence of antigen-specific T-cells in the lung interstitium. Recent advances in intravascular staining have allowed us to reassess the previously established T-cell distribution profile and its relationship with the observed differential protection. Respiratory mucosal immunisation empowers T-cells to home to both the lung interstitium and the airway lumen, whereas intramuscular immunisation-activated T-cells are largely trapped within the pulmonary vasculature, unable to populate the lung interstitium and airway. Given the mounting evidence supporting the safety and enhanced efficacy of respiratory mucosal immunisation over the traditional parenteral immunisation route, a greater effort should be made to clinically develop respiratory mucosal-deliverable TB vaccines.
ISSN 16000617
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2015-06-01
e-ISSN 09059180
Journal European Respiratory Review
Volume Number 24
Issue Number 136
Page Count 5
Starting Page 356
Ending Page 360


Source: Directory of Open Access Journals (DOAJ)