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Author Behr, Jürgen
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher European Respiratory Society
File Format HTM / HTML
Date Created 2013-06-10
Copyright Year ©2013
Language English
Subject Domain (in LCC) RC705-779
Subject Keyword Cochrane ♦ Diseases of the respiratory system ♦ Pirfenidone ♦ Internal medicine ♦ Guidelines ♦ Medicine ♦ Idiopathic pulmonary fibrosis ♦ Evidence based ♦ Treatment recommendations ♦ Specialties of internal medicine
Abstract Recently updated guidelines have provided revised recommendations, based on the GRADE criteria, for the diagnosis and pharmacological and non-pharmacological management of patients with idiopathic pulmonary fibrosis (IPF). Cochrane reviews are also a highly respected and reliable source of evidence-based information that identify and analyse all available data of overall treatment effects from appropriate studies. A recent update of one Cochrane review failed to identify any new evidence supporting the use of corticosteroids in IPF. Another review of data from 15 randomised controlled studies of non-steroid agents for the treatment of IPF identified two trials of interferon-γ-1b suitable for analysis. However, the pooled analysis revealed no treatment effect in terms of survival. A further meta-analysis of three phase III studies of pirfenidone treatment in IPF patients suggested a significant increase in progression-free survival. The interpretation of recent international and national European guideline updates and treatment recommendations, available clinical data from published and ongoing trials investigating potential pharmacological agents, and the individual patient's preferences, must be considered in the clinical management of this disease.
ISSN 16000617
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2013-06-01
e-ISSN 09059180
Journal European Respiratory Review
Volume Number 22
Issue Number 128
Page Count 6
Starting Page 163
Ending Page 168


Source: Directory of Open Access Journals (DOAJ)