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Author Davenport, A. ♦ Vachiéry, Jl
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher European Respiratory Society
File Format HTM / HTML
Date Created 2010-02-19
Copyright Year ©2009
Language English
Subject Domain (in LCC) RC705-779
Subject Keyword Endothelin ♦ Chronic kidney disease ♦ Diseases of the respiratory system ♦ Pulmonary hypertension ♦ Internal medicine ♦ Medicine ♦ Specialties of internal medicine
Abstract Endothelial cells regulate vascular tone largely by the actions of endothelin-1. Endothelin-1 is a potent vasoconstrictor, with effects that are dependent on the receptors to which it binds as well as their location. Endothelin-1 dysregulation is implicated in pathological conditions, including those of the pulmonary vasculature and the kidney. In this review, we describe the physiology and actions of endothelin-1 in lung and renal tissues and discuss therapies that disrupt these interactions in disease states. We provide an overview of the current clinical progress of these targeted agents and provide perspectives on the treatment of pulmonary and renal diseases with endothelin receptor antagonists.
ISSN 16000617
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2009-12-01
e-ISSN 09059180
Journal European Respiratory Review
Volume Number 18
Issue Number 114
Page Count 12
Starting Page 260
Ending Page 271


Source: Directory of Open Access Journals (DOAJ)