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Author Khanna, Dinesh ♦ Coghlan, J. Gerry ♦ Schwaiger, Johannes P.
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher European Respiratory Society
File Format HTM / HTML
Date Created 2013-12-02
Copyright Year ©2013
Language English
Subject Domain (in LCC) RC705-779
Subject Keyword Diseases of the respiratory system ♦ Internal medicine ♦ Medicine ♦ Specialties of internal medicine
Abstract Pulmonary arterial hypertension (PAH) is a progressive vasculopathy that is advanced by the time symptoms develop. As symptoms are nonspecific and the condition uncommon, continued progression toward end-stage disease occurs for an average of 2 years between symptom onset and diagnosis. There is need for earlier diagnosis and treatment, as most patients are severely symptomatic when diagnosed and their mortality is high despite therapy. Screening can help; however, it is not straightforward due to the diversity of patient profiles and lack of sufficiently accurate tools. Echocardiography, currently the best available screening tool, lacks both sensitivity and specificity. The low prevalence of PAH renders many screening tools unfit for purpose. However, this may be overcome, in some instances, by using enrichment tools to preselect screening populations. The majority of data are available for systemic sclerosis. A recent study has demonstrated how lung function can be used to enrich PAH prevalence in a systemic sclerosis population. A screening bundle then selects patients for right heart catheterisation with improved rates of sensitivity compared to current guidelines.
ISSN 16000617
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2013-12-01
e-ISSN 09059180
Journal European Respiratory Review
Volume Number 22
Issue Number 130
Page Count 11
Starting Page 515
Ending Page 525


Source: Directory of Open Access Journals (DOAJ)