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Author Liset Menendez De La Prida ♦ Mazarati, Andrey ♦ Jones, Nigel C. ♦ Galanopoulou, Aristea S. ♦ Harte-Hargrove, Lauren C. ♦ Kalynchuk, Lisa E. ♦ Lenck-Santini, Pierre-Pascal ♦ Medel-Matus, Jesús-Servando ♦ Nehlig, Astrid ♦ Liset Menendez de la Prida ♦ Sarkisova, Karine ♦ Veliskova, Jana
Source Hyper Articles en Ligne (HAL)
Content type Text
Publisher The International League Against Epilepsy
File Format PDF
Language English
Subject Keyword Animal models ♦ Behavior ♦ Comorbidities ♦ Epilepsy ♦ sdv ♦ Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Abstract The provided companion has been developed by the Behavioral Working Group of the Joint Translational Task Force of the International League Against Epilepsy (ILAE) and the American Epilepsy Society (AES) with the purpose of assisting the implementation of Preclinical Common Data Elements (CDE) for studying and for reporting neurobehavioral comorbidities in rodent models of epilepsy. Case Report Forms (CRFs) are provided, which should be completed on a per animal/per test basis, whereas the CDEs are a compiled list of the elements that should be reported. This companion is not designed as a list of recommendations, or guidelines for how the tests should be run-rather, it describes the different types of assessments, and highlights the importance of rigorous data collection and transparency in this regard. The tests are divided into 7 categories for examining behavioral dysfunction on the syndrome level: deficits in learning and memory; depression; anxiety; autism; attention deficit/ hyperactivity disorder; psychosis; and aggression. Correspondence and integration of these categories into the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) is introduced. Developmental aspects are addressed through the introduction of developmental milestones. Discussion includes complexities, limitations , and biases associated with neurobehavioral testing, especially when performed in animals with epilepsy, as well as the importance of rigorous data collection and of transparent reporting. This represents, to our knowledge, the first such resource dedicated to preclinical CDEs for behavioral testing of rodents.
ISSN 24709239
Educational Use Research
Learning Resource Type Article
Publisher Date 2018-11-01
Journal Epilepsia Open
Volume Number 3
Page Count 29
Starting Page 24
Ending Page 52