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Author Deutsch, M. ♦ Rewers, A. B. ♦ Redgate, S. ♦ Fisher, E. R. ♦ Boggs, S. S.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. ♦ BRAIN ♦ NEOPLASMS ♦ DEOXYURIDINE ♦ RADIOSENSITIVITY EFFECTS ♦ COMBINED THERAPY ♦ CEREBROSPINAL FLUID ♦ EXPERIMENTAL NEOPLASMS ♦ RADIOSENSITIZERS ♦ RATS ♦ SURVIVAL TIME ♦ ANIMALS ♦ ANTIMETABOLITES ♦ AZINES ♦ BIOLOGICAL MATERIALS ♦ BODY ♦ BODY FLUIDS ♦ CENTRAL NERVOUS SYSTEM ♦ DISEASES ♦ DRUGS ♦ HETEROCYCLIC COMPOUNDS ♦ HYDROXY COMPOUNDS ♦ MAMMALS ♦ MATERIALS ♦ NERVOUS SYSTEM ♦ NUCLEOSIDES ♦ NUCLEOTIDES ♦ ORGANIC COMPOUNDS ♦ ORGANIC NITROGEN COMPOUNDS ♦ ORGANS ♦ PYRIMIDINES ♦ RIBOSIDES ♦ RODENTS ♦ THERAPY ♦ URACILS ♦ VERTEBRATES ♦ Medicine- External Radiation in Therapy- (1980-) ♦ Radiation Effects on Animals- Animals
Abstract The efficacy of 5-iodo-2-deoxyuridine (IUDR) as a radiosensitizer when administered by continuous infusion into the cerebral spinal fluid (CSF) of the lateral cerebral ventricle was evaluated in a 9L gliosarcoma rat brain tumor model. Stereotactic implantation of a 5 x 10(4) tumor cell suspension into the left caudate nucleus was carried out in four groups of 10 rats each. Control animals had a median survival of 16.9 days (range 16-21 days). IUDR, 8.4 mg over 7 days administered by continuous infusion into the left lateral ventricle produced a slight survival advantage (median survival 21.5 days, range 12-56). Irradiation of the entire brain, 8 Gy on days 4, 6 and 7 after tumor cell implantation also produced a slight improvement in survival (median 19.5 days, range 17-34). The combination of radiation and IUDR infusion into the CSF produced a marked survival advantage (median 30.5, range 22-54) compared to the control and single modality treatment groups. This is the first demonstration of the effectiveness of IUDR as a radiosensitizer when administered into the lateral cerebral ventricle in the treatment of an intraparenchymal brain tumor.
ISSN 03603016
Educational Use Research
Learning Resource Type Article
Publisher Date 1990-07-01
Publisher Place United States
Journal International Journal of Radiation Oncology, Biology and Physics
Volume Number 19
Issue Number 1


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