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Author Sato, Hiroki ♦ Soh, Junichi ♦ Hotta, Katsuyuki ♦ Katsui, Kuniaki ♦ Kanazawa, Susumu ♦ Kiura, Katsuyuki ♦ Toyooka, Shinichi
Source J-STAGE
Content type Text
Publisher The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery
Language English
Subject Keyword chemoradiotherapy ♦ non-small-cell lung cancer ♦ superior vena cava
Abstract Purpose: The purpose of this study is to explore the possibility of surgery after chemoradiotherapy (CRT) for locally advanced-non-small-cell lung cancer (LA-NSCLC) with superior vena cava (SVC) resection in terms of prognosis and early and late postoperative course.Methods: The medical records of NSCLC patients who underwent surgery after CRT at our institution between January 2001 and March 2016 were reviewed. We evaluated the feasibility of surgery with SVC resection after CRT.Results: A total of 8 LA-NSCLC patients were enrolled in this study. The SVC management included a graft replacement in two patients, pericardial patch repair in two, and direct suture closure in four. A complete resection was achieved in seven of the eight patients (87.5%). Postoperative early and late complication rate (Clavien-Dindo classification ≥ grade III) was 25%. All the complications were manageable, and no treatment-related deaths occurred in this series. Although seven out of eight patients showed good patency of reconstructed SVC, one patient exhibited the SVC occlusion during long-term follow-up period. Regarding the prognosis, the 5-year overall survival (OS) rate was 60.0%, and the 2-year recurrence-free survival (RFS) rate was 75.0%.Conclusion: Our results suggest that surgery with SVC resection after CRT is a feasible procedure in terms of clinical outcomes and postoperative course.
ISSN 13411098
Learning Resource Type Article
Publisher Date 2018-01-01
e-ISSN 21861005
Journal Annals of Thoracic and Cardiovascular Surgery(atcs)
Volume Number 24
Issue Number 3
Page Count 8
Starting Page 131
Ending Page 138


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