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Author Rosa, A. C. ♦ Fantozzi, R.
Source PubMed Central
Content type Text
Publisher Blackwell Publishing Ltd
File Format PDF
Date Created 2013-06-04
Copyright Year ©2013
Language English
Difficulty Level Medium
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Pharmacology
Abstract The term ‘neurogenic inflammation’ has been adopted to describe the local release of inflammatory mediators, such as substance P and calcitonin gene-related peptide, from neurons. Once released, these neuropeptides induce the release of histamine from adjacent mast cells. In turn, histamine evokes the release of substance P and calcitonin gene-related peptide; thus, a bidirectional link between histamine and neuropeptides in neurogenic inflammation is established. The aim of this review is to summarize the most recent findings on the role of histamine in neurogenic inflammation, with particular regard to nociceptive pain, as well as neurogenic inflammation in the skin, airways and bladder.
ISSN 00071188
Age Range above 22 year
Educational Use Research
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2013-09-01
Rights Holder Blackwell Publishing Ltd
e-ISSN 14765381
Journal British Journal of Pharmacology
Volume Number 170
Issue Number 1
Page Count 8
Starting Page 38
Ending Page 45


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Source: PubMed Central