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Author Vinall, Christopher ♦ Stevens, Lucy ♦ Mcardle, Paul
Source PubMed Central
Content type Text
Publisher BMJ Publishing Group
File Format PDF
Copyright Year ©2013
Language English
Difficulty Level Medium
Subject Domain (in DDC) Technology ♦ Medicine & health
Abstract Pemphigus vulgaris (PV) is a rare but potentially life-threatening autoimmune disease affecting the mucosa and the skin. The disease is caused by circulating antibodies to desmosomes (important adhesion proteins linking cells together). Disruption of these intercellular connections results in a loss of cohesion between cells (acantholysis). The clinical result of this process is the development of multiple blisters that easily rupture, leaving behind painful sloughing eroded areas of mucosa and/or skin. We report a case of severe PV in a 56-year-old man presenting with widespread, painful, eroded mucocutaneous lesions. The severity of the disease demanded a range of medical and surgical specialties to successfully manage the problem. This paper highlights the importance of an early multidisciplinary team approach to improve the outcome of patients suffering with this disease.
ISSN 1757790X
Age Range above 22 year
Educational Use Research
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2013-12-16
Rights Holder BMJ Publishing Group
e-ISSN 1757790X
Journal BMJ Case Reports
Volume Number 2013
Starting Page 2013200479


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Source: PubMed Central