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Author Vicaut, E. ♦ Chibbaro, Salvatore ♦ Mateo, J. ♦ Gobron, C. ♦ Romano, A. ♦ Ippolito, M. ♦ Vallee, F. ♦ George, B. ♦ Poczos, P. ♦ Beccaria, K. ♦ Fricia, M. ♦ Ippolito, S. ♦ Guichard, J. P.
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Thieme Medical and Scientific Publishers
File Format HTM / HTML
Date Created 2015-08-11
Copyright Year ©2012
Language English
Subject Domain (in LCC) RD1-811 ♦ RC346-429
Subject Keyword Biological psychiatry ♦ Neurosciences ♦ Cranioplasty ♦ Internal medicine ♦ Brain cerebral brain perfusion ♦ Medicine ♦ Neuropsychiatry ♦ Brain glucose metabolism ♦ Diseases of the nervous system ♦ Cognitive and functional outcome ♦ Syndrome of the sinking bone flap ♦ Neurology ♦ Surgery
Abstract Background: The main indications for cranial reconstruction following decompressive craniectomy at present are cerebral protection and the cosmetic repair. Many reports about neurological improvement after cranioplasty are now available in the literature; however, the underlying patho-physiological mechanisms are still unknown. Materials and Methods: Thirty four patients undergoing decompressive craniectomy for severe head injury and early cranioplasty were prospectively studied. Clinical outcome was evaluated by GOS, FAB and MMSE, 3 days prior and 1 and 6 months after surgery; Trans-cranial Doppler and 18 FDG PET scan were also performed (to explore local and global brain hemodynamic and metabolic changes) 3 days prior to, and 30 days after cranial reconstruction. Results: Cranioplasty improved local and global cerebral brain perfusion (CBF) as well as brain metabolism in all 34 (100%) patients. Ninety-one % of patients showed also a clear and remarkable neuro-cognitive improvement tested by GOS, FAB and MMSE in the post-cranioplasty period. Conclusion: Cranial reconstruction has an effect upon local as well as global brain CBF and metabolism, constituting probably an essential factor influencing the final functional and especially cognitive outcome in a patient.
ISSN 2277954X
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2012-01-01
e-ISSN 22779167
Journal Indian Journal of Neurosurgery
Volume Number 1
Issue Number 1
Page Count 6
Starting Page 17
Ending Page 22


Source: Directory of Open Access Journals (DOAJ)