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Author Huang, Shanshan ♦ Chen, Yinyin ♦ Liu, Bei ♦ He, Fei ♦ Ma, Ping’an ♦ Deng, Xiaoran ♦ Cheng, Ziyong ♦ Lin, Jun
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY ♦ CALCINATION ♦ CARBONATES ♦ CONTRAST MEDIA ♦ DELIVERY ♦ DOXORUBICIN ♦ ERBIUM IONS ♦ EXCITATION ♦ IRON OXIDES ♦ LUMINESCENCE ♦ NANOCOMPOSITES ♦ NEOPLASMS ♦ NMR IMAGING ♦ POROUS MATERIALS ♦ REDUCTION ♦ SILICON OXIDES ♦ SYNTHESIS ♦ TOXICITY ♦ UREA ♦ VISIBLE RADIATION ♦ YTTERBIUM IONS
Abstract Multifunctional hollow nanocapsules with magnetic and upconversion luminescence properties were synthesized. Hollow Fe{sub 3}O{sub 4}@SiO{sub 2} was firstly prepared by using rodlike β-FeOOH as the template followed by silica coating, calcinations and reduction. Then Fe{sub 3}O{sub 4}@SiO{sub 2}@α-NaYF{sub 4}:Yb{sup 3+},Er{sup 3+} nanocapsules (FeSiUCNP) were synthesized by the hydrothermal transformation of the Y(Yb{sup 3+}, Er{sup 3+})(OH)CO{sub 3} (YOC) deposited onto the surface of nanocapsules through a urea-assisted homogeneous precipitation method. The hollow nanocapsules with porous structure provide space and entrance for the drug molecules. Due to the outside shell of α-NaYF{sub 4}:Yb{sup 3+}, Er{sup 3+}, the nanomaterial shows upconverting red emission upon 980 nm NIR-light excitation. Moreover, the nanocomposites with hollow magnetite core exhibit a high relaxivity with r{sub 2} value of 183 mM{sup −1} s{sup −1}, which reveal the potential as T{sub 2}-weighted contrast agents for magnetic resonance imaging (MRI). The as-prepared nanocapsules can be performed as anti-cancer drug carriers for investigation of drug loading/release properties, which demonstrated a sustained drug release pattern and a comparable cytotoxicity with free doxorubicin (DOX). The multifunctional nanocapsules incorporated upconverting luminescence, T{sub 2}-weighted MRI imaging and drug targeting delivery modalities have great potential for theranostic applications in cancer treatment. - Graphical abstract: Multifunctional hollow nanocapsules with upconverting luminescence, T{sub 2}-weighted MRI imaging and drug targeting delivery modalities were synthesized for cancer treatment. - Highlights: • Multifunctional porous Fe{sub 3}O{sub 4}@SiO{sub 2}@α-NaYF{sub 4}:Yb{sup 3+},Er{sup 3+} nanocapsules were synthesized. • The nanocapsules show upconverting red emission upon 980 nm NIR-light excitation. • The nanocapsules exihibit potential as T{sub 2}-weighted contrast agents for MRI. • The DOX loaded nanocapsules demonstrated a comparable cytotoxicity with free DOX.
ISSN 00224596
Educational Use Research
Learning Resource Type Article
Publisher Date 2015-09-15
Publisher Place United States
Journal Journal of Solid State Chemistry
Volume Number 229


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