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Author Pollack, L. ♦ Tate, M. W. ♦ Finnefrock, A. C. ♦ Kalidas, C. ♦ Trotter, S. ♦ Darnton, N. C. ♦ Lurio, L. ♦ Austin, R. H. ♦ Batt, C. A. ♦ Gruner, S. M.
Sponsorship (US)
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Publisher The American Physical Society
Language English
Subject Keyword PARTICLE ACCELERATORS ♦ CATTLE ♦ CHAINS ♦ MONITORS ♦ PROTEINS ♦ SCATTERING ♦ WIGGLER MAGNETS
Abstract High-intensity, ''pink'' beam from an undulator was used in conjunction with microfabricated rapid-fluid mixing devices to monitor the early events in protein folding with time resolved small angle x-ray scattering. This Letter describes recent work on the protein bovine {beta} -lactoglobulin where collapse from an expanded to a compact set of states was directly observed on the millisecond time scale. The role of chain collapse, one of the initial stages of protein folding, is not currently understood. The characterization of transient, compact states is vital in assessing the validity of theories and models of the folding process.
ISSN 00319007
Educational Use Research
Learning Resource Type Article
Publisher Date 2001-05-21
Publisher Place United States
Journal Physical Review Letters
Volume Number 86
Issue Number 21


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