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Author Grome, Michael W. ♦ Zhang, Zhao ♦ Pincet, Frédéric ♦ Lin, Chenxiang
Source Hyper Articles en Ligne (HAL)
Content type Text
Publisher Wiley-VCH Verlag
File Format PDF
Language English
Subject Keyword sdv ♦ Life Sciences [q-bio]/Cellular Biology
Abstract A major goal of nanotechnology and bioengineering is to build artificial nanomachines capable of generating specific membrane curvatures on demand. Inspired by natural membrane‐deforming proteins, we designed DNA‐origami curls that polymerize into nanosprings and show their efficacy in vesicle deformation. DNA‐coated membrane tubules emerge from spherical vesicles when DNA‐origami polymerization or high membrane‐surface coverage occurs. Unlike many previous methods, the DNA self‐assembly‐mediated membrane tubulation eliminates the need for detergents or top‐down manipulation. The DNA‐origami design and deformation conditions have substantial influence on the tubulation efficiency and tube morphology, underscoring the intricate interplay between lipid bilayers and vesicle‐deforming DNA structures.
ISSN 14337851
Educational Use Research
Learning Resource Type Article
Publisher Date 2018-05-04
e-ISSN 15213773
Journal Angewandte Chemie International Edition
Volume Number 57
Issue Number 19
Page Count 5
Starting Page 5330
Ending Page 5334