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Author Garige, Mamatha ♦ Walters, Eric
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ ADHESION ♦ BIOLOGICAL FUNCTIONS ♦ CURCUMIN ♦ ENZYMES ♦ GENES ♦ HOMEOSTASIS ♦ OXYGEN
Abstract The molecular basis for nutraceutical properties of the polyphenol curcumin (Curcuma longa, Turmeric) is complex, affecting multiple factors that regulate cell signaling and homeostasis. Here, we report the effect of curcumin on cellular and developmental mechanisms in the eukaryotic model, Dictyostelium discoideum. Dictyostelium proliferation was inhibited in the presence of curcumin, which also suppressed the prestarvation marker, discoidin I, members of the yakA-mediated developmental signaling pathway, and expression of the extracellular matrix/cell adhesion proteins (DdCAD and csA). This resulted in delayed chemotaxis, adhesion, and development of the organism. In contrast to the inhibitory effects on developmental genes, curcumin induced gstA gene expression, overall GST activity, and generated production of reactive oxygen species. These studies expand our knowledge of developmental and biochemical signaling influenced by curcumin, and lends greater consideration of GST enzyme function in eukaryotic cell signaling, development, and differentiation.
ISSN 0006291X
Educational Use Research
Learning Resource Type Article
Publisher Date 2015-11-13
Publisher Place United States
Journal Biochemical and Biophysical Research Communications
Volume Number 467
Issue Number 2


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