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Author Trebinjac, Suad ♦ Džumhursarić, Amra ♦ Mujićskikić, Emela ♦ Avdić, Dijana
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
File Format HTM / HTML
Date Created 2018-03-26
Copyright Year ©2008
Language English
Subject Domain (in LCC) R5-920
Subject Keyword Medicine
Abstract Combination of insulin and metformin has been shown to improve glycaemic control in clinical trials, particularly in obese patients with diabetes type 2. Insulin therapy can improve function of pancreatic beta cells and periphery insulin activity in target cells in order to enhance glycaemic homeostasis (1, 2, 3). In our study we included obese patients with diabetes type 2 in the early stage of the disease. The study is partially retrospective and partially prospective. The study encompassed 40 patients split in two groups. The first group of 20 patientsreceived insulin therapy combined with metformin, while the patients of the second group were treated with oral antidiabetic drugs, sulfonylureas and metformin. Three months later, the group treated with insulin and metformin showed improvement in the monitored parameters, namely significant reduction in HbA1c (p = 0.003), MFBG (p = 0.0009), PPG (p = 0.028). Insulin therapy administered together with metformin, in obese patients with diabetes type 2, in the early stage of the disease, resulted in well regulated fasting blood glycaemia, as well as post challenge glycaemia and HbA1c.
ISSN 15128601
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2008-08-01
e-ISSN 15128601
Journal Bosnian Journal of Basic Medical Sciences
Volume Number 6
Issue Number 3
Page Count 7
Starting Page 61
Ending Page 67


Source: Directory of Open Access Journals (DOAJ)