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Author Nakašićindić, Emina ♦ Začiragić, Asija ♦ Hadžović, Almira ♦ Avdagić, Nešina
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
File Format HTM / HTML
Date Created 2018-05-29
Copyright Year ©2004
Language English
Subject Domain (in LCC) R5-920
Subject Keyword Endothelin ♦ Physiological and pathophysio-logical effects ♦ Medicine
Abstract Endothelin is a recently discovered peptide composed of 21 amino acids. There are three endothelin isomers: endothelin -1 (ET-1), endothelin -2 (ET-2) and endothelin - 3 (ET-3). In humans and animals levels of ET-1, ET-2, ET-3 and big endothelin in blood range from 0,3 to 3 pg/ml. ET-1, ET-2 and ET-3 act by binding to receptors. Two main types of the receptors for endothelins exist and they are referred to as A and B type receptors. Different factors can stimulate or inhibit production of endothelin by endothelial cells. Mechanical stimulation of endothehum, thrombin, calcium ions, epinephrine, angiotensin II, vasopressin, dopamine, cytokines, growth factors stimulate the production of endothelin whereas nitric oxide, cyclic guanosine monophosphate, atrial natriuretic peptide, prostacyclin, bradykinin inhibit its production. Endothelins have different physiological roles in human body but at the same time their actions are involved in the pathogenesis of many diseases.The aim of this review was to present some of, so far, the best studied physiological roles of endothelin and to summarize evidence supporting the potential role of ET in the pathogenesis of certain diseases.
ISSN 15128601
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2004-08-01
e-ISSN 15128601
Journal Bosnian Journal of Basic Medical Sciences
Volume Number 4
Issue Number 3
Page Count 4
Starting Page 31
Ending Page 34

Source: Directory of Open Access Journals (DOAJ)