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Author Chang, Jee Suk ♦ Choi, Seo Hee ♦ Lee, Youngin ♦ Kim, Kyung Hwan ♦ Park, Jeong Youp ♦ Song, Si Young ♦ Cho, Arthur ♦ Yun, Mijin ♦ Lee, Jong Doo ♦ Seong, Jinsil
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ FLUORINE 18 ♦ FLUORODEOXYGLUCOSE ♦ METASTASES ♦ NEOPLASMS ♦ PANCREAS ♦ PATIENTS ♦ POSITRON COMPUTED TOMOGRAPHY ♦ THERAPY ♦ TOXICITY ♦ UPTAKE
Abstract Purpose: To assess the role of coregistered {sup 18}F-fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting radiographically occult distant metastasis (DM) at staging in patients with locally advanced pancreatic cancer (LAPC) and to study whether FDG-PET parameters can predict relatively long-term survival in patients who are more likely to benefit from chemoradiation therapy (CRT). Methods and Materials: From our institutional database, we identified 388 LAPC patients with M0 on conventional computed tomography (CT) who were planned to undergo CRT. Coregistered FDG-PET staging was offered to all patients, and follow-up FDG-PET was used at the clinical discretion of the physician. Results: FDG-PET detected unsuspected CT-occult DM in 33% of all 388 patients and allowed them to receive systemic therapy immediately. The remaining 260 patients (PET-M0) underwent CRT selectively as an initial treatment. Early DM arose in 13.1% of 260 patients, and the 1-year estimated locoregional recurrence rate was 5.4%. Median overall survival (OS) and progression-free survival (PFS) were 14.6 and 9.3 months, respectively, at a median follow-up time of 32.3 months (range, 10-99.1 months). Patients with a baseline standardized uptake value (SUV) <3.5 and/or SUV decline ≥60% had significantly better OS and PFS than those having none, even after adjustment for all potential confounding variables (all P<.001). Conclusions: FDG-PET can detect radiographically occult DM at staging in one-third of patients and spare them from the potentially toxic therapy. Additionally, FDG-PET parameters including baseline SUV and SUV changes may serve as useful clinical markers for predicting the prognosis in LAPC patients.
ISSN 03603016
Educational Use Research
Learning Resource Type Article
Publisher Date 2014-09-01
Publisher Place United States
Journal International Journal of Radiation Oncology, Biology and Physics
Volume Number 90
Issue Number 1


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