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Author Alves, Jorge ♦ Soares, José Miguel ♦ Sampaio, Adriana ♦ Gonçalves, Óscar F.
Source SpringerLink
Content type Text
Publisher Springer US
File Format PDF
Copyright Year ©2013
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Alzheimer’s disease (AD) ♦ Posterior cortical atrophy ♦ Magnetic resonance imaging (MRI) ♦ Voxel-based morphometry (VBM) ♦ Meta-analysis ♦ Effect Size Signed Differential Mapping (ES-SDM) ♦ Neurosciences ♦ Neuroradiology ♦ Neuropsychology ♦ Psychiatry
Abstract This paper presents the first systematic review and meta-analysis of neuropsychological and brain morphometry studies comparing posterior cortical atrophy (PCA) to typical Alzheimer’s disease (tAD). Literature searches were conducted for brain morphometry and neuropsychological studies including a PCA and a tAD group. Compared to healthy controls (HC), PCA patients exhibited significant decreases in temporal, occipital and parietal gray matter (GM) volumes, whereas tAD patients showed extensive left temporal atrophy. Compared to tAD patients, participants with PCA showed greater GM volume reduction in the right occipital gyrus extending to the posterior lobule. In addition, PCA patients showed less GM volume loss in the left parahippocampal gyrus and left hippocampus than tAD patients. PCA patients exhibit significantly greater impairment in Immediate Visuospatial Memory as well as Visuoperceptual and Visuospatial Abilities than patients with tAD. However, tAD patients showed greater impairment in Delayed Auditory/Verbal Memory than patients with PCA. PCA is characterized by significant atrophy of the occipital and parietal regions and severe impairments in visuospatial functioning.
ISSN 19317557
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2013-05-21
Publisher Place Boston
e-ISSN 19317565
Journal Brain Imaging and Behavior
Volume Number 7
Issue Number 3
Page Count 9
Starting Page 353
Ending Page 361


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Source: SpringerLink