Access Restriction

Author Córdova Palomera, Aldo ♦ Reus, Marcel A. ♦ Fatjó Vilas, Mar ♦ Falcón, Carles ♦ Bargalló, Nuria ♦ Heuvel, Martijn P. ♦ Fañanás, Lourdes
Source SpringerLink
Content type Text
Publisher Springer US
File Format PDF
Copyright Year ©2016
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword FKBP5 ♦ Hippocampus ♦ Depression ♦ Brain network ♦ MZ twins ♦ DWI ♦ Neurosciences ♦ Neuroradiology ♦ Neuropsychology ♦ Psychiatry
Abstract The hippocampus is a key modulator of stress responses underlying depressive behavior. While FKBP5 has been found associated with a large number of stress-related outcomes and hippocampal features, its potential role in modifying the hippocampal communication transfer mechanisms with other brain regions remains largely unexplored. The putative genetic or environmental roots of the association between depression and structural connectivity alterations of the hippocampus were evaluated combining diffusion weighted imaging with both a quantitative genetics approach and molecular information on the rs1360780 single nucleotide polymorphism, in a sample of 54 informative monozygotic twins (27 pairs). Three main results were derived from the present analyses. First, graph-theoretical measures of hippocampal connectivity were altered in depression. Specifically, decreased connectivity strength and increased network centrality of the right hippocampus were found in depressed individuals. Second, these hippocampal alterations are potentially driven by familial factors (genes plus shared environment). Third, there is an additive interaction effect between FKBP5’s rs1360780 variant and the graph-theoretical metrics of hippocampal connectivity to influence depression risk. Our data reveals alterations of the communication patterns between the hippocampus and the rest of the brain in depression, effects potentially driven by overall familial factors (genes plus shared twin environment) and modified by the FKBP5 gene.
ISSN 19317557
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2016-01-22
Publisher Place New York
e-ISSN 19317565
Journal Brain Imaging and Behavior
Volume Number 11
Issue Number 1
Page Count 14
Starting Page 62
Ending Page 75

Open content in new tab

   Open content in new tab
Source: SpringerLink