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Author Chen, Ji ♦ Lin, In Tsang ♦ Zhang, Haiyan ♦ Lin, Jianzhong ♦ Zheng, Shili ♦ Fan, Ming ♦ Zhang, Jiaxing
Source SpringerLink
Content type Text
Publisher Springer US
File Format PDF
Copyright Year ©2015
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Chronic obstructive pulmonary disease ♦ Surface-based morphometry ♦ Cortical thinning ♦ Visuospatial deficits ♦ MRI ♦ Hypoxia ♦ Neurosciences ♦ Neuroradiology ♦ Neuropsychology ♦ Psychiatry
Abstract Neural impairments accompanying chronic obstructive pulmonary disease (COPD) have received growing research attention. Previous neuroimaging studies exclusively used volumetric methods to measure cortical volume as a whole rather than focusing on anatomical and neuropathological distinct indices. Here we decomposed the cortical architecture into cortical thickness (CTh), surface area (SA), and gyrification, for the first time, to provide a more integrative profile of brain damage in COPD. Clinical T1-weighted MRI scans were acquired in 25 stable COPD patients (mean age 69) and 25 age-matched controls. Images were processed using surface-based morphometry to obtain cortical parameters enabling more accurate measurement in deep sulci and localized regional mapping. Demographic, physiological, and cognitive assessments were made and correlated with cortical indices. Compared to controls, COPD patients showed significantly reduced CTh broadly distributed in motor, parietal, and prefrontal cortices, together with more circumscribed SA reduction in dorsomedial prefrontal cortex and Broca’s area (cluster-level P < 0.05 corrected). No abnormal gyrification was detected. Decreased CTh in parietofrontal networks strongly correlated with visuospatial construction impairment in COPD patients. Furthermore, thinner dorsolateral prefrontal cortex (DLPFC) best predicted poorer performance (r $^{ 2 }$ = 0.315, P = 0.004), and was associated with lower arterial oxygen saturation. These data indicate that cortical thinning is a key morphologic feature associated with COPD that could be partly attributed to oxygen desaturation and contributes to COPD visual memory and drawing deficits. Surface-based morphometry provides valuable information concerning COPD, and could ultimately help us to characterize the neurodegenerative pattern and to clarify neurologic mechanisms underlying cognitive dysfunction in COPD patients.
ISSN 19317557
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2015-05-19
Publisher Place New York
e-ISSN 19317565
Journal Brain Imaging and Behavior
Volume Number 10
Issue Number 2
Page Count 13
Starting Page 464
Ending Page 476


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Source: SpringerLink