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Author Filbey, Francesca M. ♦ Chen, Gang ♦ Sunderland, Trey ♦ Cohen, Robert M.
Source SpringerLink
Content type Text
Publisher Springer-Verlag
File Format PDF
Copyright Year ©2010
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword fMRI ♦ APOE ♦ Alzheimer’s disease ♦ Working memory ♦ Compensation ♦ Health Psychology ♦ Child and School Psychology ♦ Clinical Psychology ♦ Cognitive Psychology ♦ Neuropsychology ♦ Public Health/Gesundheitswesen
Abstract How and when the known genetic risk allele, apolipoprotein E-ε4 (APOEε4), confers risk to Alzheimer’s disease has yet to be determined. We studied older adults and found that APOEε4 carriers had greater neural activation in the medial frontal and parahippocampal gyrus during a memory task (cluster-corrected p < .01). When compared to a group of younger adults, interactive effects of age and APOEε4 were found in the inferior frontal—anterior temporal region, one of the first areas to develop amyloid plaques in patients with Alzheimer’s disease, and, in the posterior cingulate, one of the earliest areas to show decreased cerebral metabolism in Alzheimer’s disease. Thus, abnormally high activation in fronto-temporal areas are present in both younger and older APOEε4 carriers confronted with a working memory task when compared to non-APOEε4 carriers. This effect, however, appears to diminish with age.
ISSN 19317557
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2010-05-18
Publisher Place New York
e-ISSN 19317565
Journal Brain Imaging and Behavior
Volume Number 4
Issue Number 2
Page Count 12
Starting Page 177
Ending Page 188


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Source: SpringerLink