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Author Kovalev, G. I. ♦ Kondrakhin, E. A. ♦ Salimov, R. M.
Source SpringerLink
Content type Text
Publisher SP MAIK Nauka/Interperiodica
File Format PDF
Copyright Year ©2013
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword NMDA receptor ♦ benzodiazepine receptor ♦ cross-maze test ♦ radioligand binding ♦ exploratory behavior ♦ anxiety ♦ correlation analysis ♦ Neurosciences
Abstract We studied spontaneous behavior in the cross-maze test and differences in neuroreceptors in inbred C57BL/6 and BALB/c mice. Correlation and factor analysis of behavioral data showed that the indices of exploratory behavior and anxiety in a novel context were rather independent from each other. The densities of NMDA receptors (B $_{max}$, fmol/mg of protein) in the hippocampus and benzodiazepine receptors in the prefrontal cortex were higher in C57BL/6 mice. Our data demonstrate the opportunity for selective pharmacological regulation of cognitive behavior and anxiety using nootropic and anxiolytic drugs.
ISSN 18197124
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2013-06-10
Publisher Place Dordrecht
e-ISSN 18197132
Journal Neurochemical Journal
Volume Number 7
Issue Number 2
Page Count 7
Starting Page 121
Ending Page 127


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Source: SpringerLink