Thumbnail
Access Restriction
Subscribed

Author Sun, Shengai ♦ Yu, Rilei ♦ Zhang, Yanhui ♦ Li, Yanni
Source SpringerLink
Content type Text
Publisher SP Higher Education Press
File Format PDF
Copyright Year ©2010
Language English
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences
Subject Keyword mouse muscle type nAChR ♦ homology modeling ♦ molecular dynamic simulation ♦ Nanotechnology ♦ Industrial Chemistry/Chemical Engineering
Abstract A mouse muscle type nAChR model ((α1)$_{2}$βδδg) was built based on the cryoelectron microscopic structure of intact Torpedo marmorata nAChR and the high resolution crystal structure of nAChR-α1 subunit. The conformation of the pentameric nAChR model was investigated by molecular dynamic simulation. The function of water molecule in the hydrophilic interior was clarified. The reason for Tyr127 showing two alternative conformations was discussed in detail.
ISSN 16737369
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2010-01-28
Publisher Institution Chinese Universities
Publisher Place Heidelberg
e-ISSN 16737474
Journal Frontiers of Chemical Engineering in China
Volume Number 4
Issue Number 3
Page Count 5
Starting Page 348
Ending Page 352


Open content in new tab

   Open content in new tab
Source: SpringerLink