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Author Khaspekov, L. G. ♦ Sharova, I. N. ♦ Kolbaev, S. N.
Source SpringerLink
Content type Text
Publisher Pleiades Publishing
File Format PDF
Copyright Year ©2016
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword postischemic epileptogenesis ♦ in vitro modeling ♦ culture of neural cells and tissue ♦ neuroprotectors ♦ Neurosciences
Abstract We reviewed the literature data on the cellular and molecular mechanisms of postischemic epileptogenesis, which is modeled in a culture of dissociated neurons and organotypic culture of nervous tissue. We summarized the data on the involvement of glutamate excitotoxicity in the development of epileptiform discharges generated by neurons in culture after glutamate application and on the involvement of neuronal calcium overload in the formation of seizure activity. We also presented data on the effects of neuroprotectors in models of postischemic epileptogenesis in vitro.
ISSN 18197124
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2016-09-10
Publisher Place Moscow
e-ISSN 18197132
Journal Neurochemical Journal
Volume Number 10
Issue Number 3
Page Count 6
Starting Page 184
Ending Page 189


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Source: SpringerLink