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Author Us, K. S. ♦ Klodt, P. M. ♦ Kudrin, V. S. ♦ Saprova, A. Ya. ♦ Ostrovskaya, R. U. ♦ Ugryumov, M. V. ♦ Rayevsky, K. S.
Source SpringerLink
Content type Text
Publisher Allerton Press, Inc.
File Format PDF
Copyright Year ©2007
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword glutamate release ♦ brain cortex slices ♦ Noopept ♦ neuroprotective properties ♦ Neurosciences
Abstract The level of spontaneous and K$^{+}$-stimulated release of endogenous glutamate was studied in experiments on slices of brain cortex of Wistar rats. Pronounced spontaneous release of the neuromediator and its increase under conditions of stimulation were registered by high-performance liquid chromatography with electrochemical detection. The effect of the nootropic and neuroprotective dipeptide Noopept (GVS-111) on release of glutamate was investigated. The peptide in concentrations of 10$^{−5}$ and 10$^{−6}$ M caused a statistically significant decrease in spontaneous and K$^{+}$-stimulated glutamate release. This effect could be the basis of the neuroprotective action of the peptide, suggesting that further studies of Noopept as neuroprotector are very promising.
ISSN 18197124
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2007-01-01
Publisher Place New York
e-ISSN 18197132
Journal Neurochemical Journal
Volume Number 1
Issue Number 2
Page Count 5
Starting Page 138
Ending Page 142


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Source: SpringerLink