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Author Vernigora, A. N. ♦ Volkova, N. V. ♦ Saldaev, D. A.
Source SpringerLink
Content type Text
Publisher Pleiades Publishing
File Format PDF
Copyright Year ©2017
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword carboxypeptidase E ♦ PMSF-inhibited carboxypeptidase ♦ stress ♦ testosterone ♦ progesterone ♦ sex ♦ hypothalamo–pituitary–adrenal system ♦ Neurosciences
Abstract The effects of testosterone and progesterone on the activities of carboxypeptidase E and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase (PMSF-CP) after stress induced by an intraperitoneal injection of olive oil were studied in male and female mice. Sex-related differences in the activities of the studied carboxypeptidases were observed in both intact and stress-exposed animals, as well as after the injection of the steroid hormones. In females, stress and hormones mostly decreased the activity of carboxypeptidases, which resulted in the attenuation of differences between females and males. The alterations in the PMSF-CP activity were stronger than in the activity of carboxypeptidase E. The involvement of these enzymes in the mechanism of stress and formation of sex-related differences in the functioning of the hypothalamo–pituitary–adrenal system, as well as the mechanism of the effects of sex-steroid hormones on the activities of these carboxypeptidases, are discussed.
ISSN 18197124
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2017-03-25
Publisher Place Moscow
e-ISSN 18197132
Journal Neurochemical Journal
Volume Number 11
Issue Number 1
Page Count 6
Starting Page 79
Ending Page 84


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Source: SpringerLink