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Author Jamal, Mostofa ♦ Ame, Kiyoshi ♦ Tanaka, Naoko ♦ Kishita, Hiroshi
Source SpringerLink
Content type Text
Publisher Springer US
File Format PDF
Copyright Year ©2014
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword hippocampus ♦ cholinergic markers ♦ ApoE-knockout mice ♦ Neurosciences
Abstract Our recent study suggests that mice deficient in ApoE may exhibit impaired learning and memory. Here we designed the present study to investigate the association between ApoE deficiency and cholinergic markers expression in the hippocampus of ApoE-knockout (ApoE-KO) and wild-type (WT) mice. Hippocampal slices were collected and the mRNA levels of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) and the protein level of ChAT were analyzed. We show that ApoE-KO exhibited a distinctly lower ChAT mRNA and protein levels in the hippocampus compared with WT mice. There were no strain effects on AChE mRNA. Our data provide evidence supporting the role of ApoE in the expression of ChAT, which may suggest a possible link between cholinergic deficit and poorer performance in ApoE-KO mice.
ISSN 18197124
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-03-07
Publisher Place Boston
e-ISSN 18197132
Journal Neurochemical Journal
Volume Number 8
Issue Number 1
Page Count 4
Starting Page 78
Ending Page 81

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Source: SpringerLink