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Author bari, S. ♦ Mongrain, R. ♦ Leask, R. ♦ Cartier, R.
Source SpringerLink
Content type Text
Publisher Springer Berlin Heidelberg
File Format PDF
Copyright Year ©2013
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Aortic valve ♦ Coronary arteries ♦ Hemodynamic ♦ Pathologies ♦ Three-dimensional global model ♦ Fluid–structure interaction ♦ Human Physiology ♦ Biomedical Engineering ♦ Imaging ♦ Radiology ♦ Computer Applications
Abstract Pathologies of the aortic valve such as aortic sclerosis are thought to impact coronary blood flow. Recent clinical investigations have observed simultaneous structural and hemodynamic variations in the aortic valve and coronary arteries due to regional pathologies of the aortic valve. The goal of the present study is to elucidate this observed and yet unexplained phenomenon, in which a local pathology in the aortic valve region could potentially lead to the initiation or progression of coronary artery disease. Results revealed a considerable impact on the coronary flow, velocity profile, and consequently shear stress due to an increase in the aortic wall or aortic leaflet stiffness and thickness which concur with clinical observations. The cutoff value of 0.75 for fractional flow reserve was reached when the values of leaflet thickness and aortic wall stiffness were approximately twice and three times their normal value, respectively. Variations observed in coronary velocity profiles as well as wall shear stress suggest a possible link for the initiation of coronary artery disease.
ISSN 01400118
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2013-04-03
Publisher Place Berlin, Heidelberg
e-ISSN 17410444
Journal Medical and Biological Engineering and Computing
Volume Number 51
Issue Number 8
Page Count 14
Starting Page 923
Ending Page 936


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Source: SpringerLink