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Author Shtemberg, A. S. ♦ Kudrin, V. S. ♦ Klodt, P. M. ♦ Narkevich, V. B. ♦ Bazyan, A. S.
Source SpringerLink
Content type Text
Publisher SP MAIK Nauka/Interperiodica
File Format PDF
Copyright Year ©2012
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword Neurosciences
Abstract We studied the effects of models of imponderability (Antiorthostatic Hypodynamia, AH) and overload (AH + centrifugation) on discriminant learning in mice and the concentrations of monoamines and their metabolites in several brain structures. The experimental conditions accelerated the formation of the locomotor behavioral stereotype, which underlies discriminant food learning. This was accompanied by weaker food motivation of the experimental animals, as compared to the control animals. Presumably, this effect may be related to the so-called “sharpening of attention.” This occurs due to the suppression of the executive mechanisms of locomotor and exploratory activity, which decreases afferent generalization. Analysis of the concentrations of monoamines and their metabolites in the prefrontal cortex, hypothalamus, striatum, and cerebellum revealed considerable intensification of serotonin metabolism, in contrast to catecholamines. Behavioral results are discussed in the framework of the development of a negative emotional state related to the activity of the serotonergic system of the prefrontal cortex (“decision making” which is focused on escape from the negative state) and the realization of targeted behavior (“selection of action” as acquisition of rewards or food) by neuronal networks of the striatum and cerebellum. This response is possible with weak food motivation.
ISSN 18197124
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2012-11-28
Publisher Place Dordrecht
e-ISSN 18197132
Journal Neurochemical Journal
Volume Number 6
Issue Number 4
Page Count 8
Starting Page 291
Ending Page 298


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Source: SpringerLink