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Author Belenichev, I. F. ♦ Kolesnik, Yu. M. ♦ Pavlov, S. V. ♦ Sokolik, E. P. ♦ Bukhtiyarova, N. V.
Source SpringerLink
Content type Text
Publisher SP MAIK Nauka/Interperiodica
File Format PDF
Copyright Year ©2011
Language English
Subject Domain (in DDC) Technology ♦ Medicine & health
Subject Keyword mitochondrial dysfunction ♦ heat shock proteins ♦ chaperones ♦ ischemia ♦ Neurosciences
Abstract We studied the involvement of HSP70 and Hif1b genes in the development of pathological changes in the brains of experimental animals during ischemia. We found neuro- and mitoprotective characteristics of heat shock protein HSP70 and Hif1b in vitro and under cerebral ischemia due to stabilization of molecules damaged by oxidation, inhibition of nitrosative and oxidative stress and mitoprotective action directed to amelioration of mitochondrial dysfuction. The protective role of these proteins provides a new direction for the development of novel neuroprotective drugs that protect or modulate the genes that encode these proteins.
ISSN 18197124
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2011-12-07
Publisher Place Dordrecht
e-ISSN 18197132
Journal Neurochemical Journal
Volume Number 5
Issue Number 4
Page Count 6
Starting Page 251
Ending Page 256

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Source: SpringerLink