|Author||Garnon, J. ♦ Ramamurthy, N. ♦ Caudrelier, J. J. ♦ Erceg, G. ♦ Breton, E. ♦ Tsoumakidou, G. ♦ Rao, P. ♦ Gangi, A.|
|Source||United States Department of Energy Office of Scientific and Technical Information|
|Subject Keyword||RADIOLOGY AND NUCLEAR MEDICINE ♦ ACCURACY ♦ BIOPSY ♦ COMPUTERIZED TOMOGRAPHY ♦ CORRELATIONS ♦ DIAGNOSIS ♦ MASS ♦ MEDIASTINUM ♦ NEOPLASMS ♦ NITROGEN 13 ♦ NMR IMAGING ♦ PATHOLOGY ♦ PATIENTS ♦ SAFETY ♦ SENSITIVITY ♦ SPECIFICITY ♦ SURGERY|
|Abstract||ObjectiveTo evaluate the diagnostic accuracy and safety of magnetic resonance imaging (MRI)-guided percutaneous biopsy of mediastinal masses performed using a wide-bore high-field scanner.Materials and MethodsThis is a retrospective study of 16 consecutive patients (8 male, 8 female; mean age 74 years) who underwent MRI-guided core needle biopsy of a mediastinal mass between February 2010 and January 2014. Size and location of lesion, approach taken, time for needle placement, overall duration of procedure, and post-procedural complications were evaluated. Technical success rates and correlation with surgical pathology (where available) were assessed.ResultsTarget lesions were located in the anterior (n = 13), middle (n = 2), and posterior mediastinum (n = 1), respectively. Mean size was 7.2 cm (range 3.6–11 cm). Average time for needle placement was 9.4 min (range 3–18 min); average duration of entire procedure was 42 min (range 27–62 min). 2–5 core samples were obtained from each lesion (mean 2.6). Technical success rate was 100 %, with specimens successfully obtained in all 16 patients. There were no immediate complications. Histopathology revealed malignancy in 12 cases (4 of which were surgically confirmed), benign lesions in 3 cases (1 of which was false negative following surgical resection), and one inconclusive specimen (treated as inaccurate since repeat CT-guided biopsy demonstrated thymic hyperplasia). Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in our study were 92.3, 100, 100, 66.7, and 87.5 %, respectively.ConclusionMRI-guided mediastinal biopsy is a safe procedure with high diagnostic accuracy, which may offer a non-ionizing alternative to CT guidance.|
|Learning Resource Type||Article|
|Publisher Place||United States|
|Journal||Cardiovascular and Interventional Radiology|
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