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Author Kelbaek, Henning ♦ Hartling, Ölej ♦ Skagen, Knud ♦ Munck, Ole ♦ Henriksen, Ole ♦ Godtfredsen, John
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Cardiac Output ♦ Improved Gamma Camera Method ♦ Technical Note First-pass Radionuclide Determination ♦ Arterial Sampling ♦ Left Ventricular Count ♦ Intravenous Injection ♦ Distribution Volume ♦ 10-15 Mci Technetium-99m ♦ Noninvasive Evaluation ♦ Arterial Blood ♦ Red Blood Cell ♦ Excellent Correlation ♦ Noninvasive Determination ♦ Ventricular Count Rate ♦ Gamma Camera ♦ Blood Activity ♦ First Passage Time-activity Curve ♦ Cardiac Output Determination ♦ Left Ventricle ♦ Complete Mixing ♦ Heart Disease ♦ New First-pass Radionuclide Cardiographie Technique ♦ Valvular Incompetence ♦ Cardiac Output Value ♦ Useful Tool ♦ Background Subtraction ♦ Conventional Tracer Dilution Technique ♦ First-pass Radionuclide Cardiography ♦ Various Origin ♦ Cardiac Function
Abstract A technique for noninvasive determination of cardiac output by aid of first-pass radionuclide cardiography is described. After intravenous injection of 10-15 mCi technetium-99m- ("Te) labeled red blood cells the method requires (a) acquisition of a first passage time-activity curve recorded with a gamma camera over the left ventricle, (b) the background corrected left ventricular count rate recorded after complete mixing of the tracer in the circulation, and (c) determination of the distribution volume of the tracer. The method was applied in 14 patients with heart disease of various origins and evaluated against the conventional tracer dilution technique with arterial sampling of blood activity. Cardiac output determinations by external counting ranged from 2.30 to 8.56 l/min, mean ±s.d. 4.50 ±1.66 l/min and by arterial blood sampling from 1.88 to 8.96 l/min, mean ±s.d. 4.52 ±1.71 l/min. An excellent correlation was demonstrated between the two techniques, r = 0.978 (p < 0.001). When no background subtraction was applied to the left ventricular counts at equilibrium, radionuclide cardiac output values were ~40 % higher than those obtained by arterial sampling. The new first-pass radionuclide cardiographie technique may prove a useful tool in the noninvasive evaluation of cardiac function, especially in patients with arrhythmias and/or valvular incompetence.
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study