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Author Zorad, S. ♦ Jezova, D. ♦ Szabova, L. ♦ Macho, L. ♦ Tybitanclova, K.
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Insulin Receptor ♦ High Receptor Protein Content ♦ Low Number ♦ Adipose Tissue ♦ Monosodium Glutamate-induced Obesity ♦ Insulin Receptor Protein ♦ Obese Rat ♦ Adipocyte Cell Membrane ♦ High Anity ♦ High Quantity ♦ Fat Tissue Insulin Receptor ♦ General Defect ♦ Angiotensin Ii Binding ♦ At1 Receptor Protein ♦ Impaired Receptor Protein
Abstract Abstract. In order to better understand the mechanisms leading to insulin resis-tance, the number of fat tissue insulin receptors, their anity and insulin receptor protein in rats with monosodium glutamate-induced obesity were studied. Obese rats displayed signicantly lower number of insulin receptors with high anity. Sur-prisingly, the amount of insulin receptor protein was signicantly elevated in these animals. The same relations have been already reported for angiotensin II binding and AT1 receptor protein in the same model of obesity. Therefore we suggest an existence of general defect of adipocyte cell membrane in monosodium glutamate-induced obesity characterized by the presence of high quantity of impaired receptor protein.
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article