Access Restriction

Author Behar, Jose ♦ Jack, W. ♦ Zhou, Xiaoxu ♦ Li, Dan ♦ Cells, Adenocarcinoma ♦ Resnick, Murray B. ♦ Cao, Weibiao
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Abstract Mechanisms whereby acid reflux may accelerate the progres-sion from Barrett’s esophagus (BE) to esophageal adenocarci-noma (EA) are not fully understood. We have previously shown that NADPH oxidase NOX5-S generates reactive oxygen spe-cies (ROS) when Barrett’s metaplastic cells are exposed to acid. Besides metaplastic cells, other H2O2-producing cells (e.g., inflammatory cells) present in BE mucosa may produce additional ROS, which may also affect metaplastic cells con-tributing to esophageal tumorigenesis. In this study, we investi-gate whether exogenous H2O2 stimulates cell proliferation by increasing NOX5-S expression. Low dose (1013 M) of H2O2 significantly increased thymidine incorporation, NOX5-S mRNA, and protein expression in a Barrett’s EA cell line FLO. H2O2-induced increase in NOX5-S expression was significantly inhibited
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Publisher Date 2011-01-01