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Author Forebrain, Finch Anterior
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Nmda Receptor ♦ Ifenprodil Binding ♦ Fast Track Developmental Regulation ♦ Song Learning ♦ Subunit Mrna ♦ Anterior Forebrain ♦ Sensitive Period ♦ Developmental Change ♦ Antagonist Mk-801 Increase ♦ Young Male Zebra Finch ♦ New Song Element ♦ Ifenprodil Receptor Autoradiography ♦ Song Region ♦ Nr2b Mrna ♦ Anterior Forebrain Song Region ♦ 30day-old Male ♦ Nmda Receptor Change ♦ Significant Decrease ♦ Several Discrete Region ♦ Lateral Magnocellular Nucleus ♦ Early Sensitive Period ♦ Adult Male ♦ Subunit Composition ♦ Situ Hybridization ♦ Passerine Songbird ♦ Anterior Neostriatum ♦ Forebrain Song Region ♦ Subunit Composition Contribute ♦ Nmda Receptor Function ♦ Male Zebra Finch ♦ Day Posthatch ♦ Developmental Decrease ♦ Nr2b Mrna Expression ♦ Developmental Regulation ♦ Nmda Receptor Pharmacology
Abstract ABSTRACT: In passerine songbirds, song learning often is restricted to an early sensitive period and requires the participation of several discrete regions within the anterior forebrain. Activation of N-methyl-Daspartate (NMDA) receptors is implicated in song learning and in one forebrain song region, the lateral magnocellular nucleus of the anterior neostriatum (lMAN), NMDA receptors decrease in density, their affinity for the antagonist MK-801 increases, and their currents decay more quickly as young male zebra finches lose the ability to imitate new song elements. These developmental changes in NMDA receptor pharmacology and physiology suggest that the subunit composition of NMDA receptors changes developmentally. Here, we have used in situ hybridization and [ 3 H]ifenprodil receptor autoradiography to study the developmental regulation of the NMDA receptor 2B subunit (NR2B) within the anterior forebrain of male zebra finches. NR2B mRNA expression within the lMAN was twice as great in 30day-old males (early in the sensitive period for song learning) as in adult males, and this developmental decrease in NR2B mRNA expression was mirrored by a decrease in high-affinity (NR2B-associated) [ 3 H]ifenprodil binding within this song region. In another anterior forebrain song region, Area X, NR2B mRNA also declined significantly after 30 days posthatch, but this decline was not accompanied by a significant decrease in [ 3 H]ifenprodil binding. The results are consistent with the hypothesis that developmental changes in NMDA receptor function mediated by regulation of subunit composition contribute to the sensitive period for vocal
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 1998-01-01