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Author Zis, Athanasios P. ♦ Haskett, Roger F. ♦ Albala, A. Ariav ♦ Carroll, Bernard J. ♦ Athanasios, P.
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Impaired Inhibitory Opioid Mechanism ♦ Possible Role ♦ Endogenous Depression ♦ Neuroendocrine Abnormality ♦ Early Resumption ♦ Healthy Volunteer ♦ Opioid Inhibitory Mechanism ♦ Several Line ♦ Cor Ol Secretion ♦ Cortisol Secretion ♦ Dexamethasone Suppression ♦ Classical Neurotransmitter-ffpa Axis Interaction ♦ Psychiatric Inpatient ♦ Neuroendocrine Abnormal Ty ♦ Evidence Indicate ♦ Abnormal Dexamethasone Suppression Test Result ♦ Psychia-tric Diagnosis ♦ Initial Suppression
Abstract Several lines of evidence indicate that the activity of the hypothalamus-pituitary-adrenal (HPA) axis in depression is disinhibited. Escape from dexamethasone suppression, although not limited to is more frequent in patients with endogenous depression compared to normals or patients with other psychia-tric diagnoses. Norepinephrine, serotonin and acetylcholine have been implicated in the pathophysiology of this neuroendocrine abnormal i ty. Morphine, 5 mg intravenously, suppressed cortisol secretion in healthy volunteers (n=4) and the majority of 32 psychiatric inpatients. However, patients with endogenous depression and abnormal dexamethasone suppression test results show early resumption (escape) of cor-&ol secretion following the initial suppression induced by morphine. It is concluded that the pathophysiology of this neuroendocrine abnormality is not limit-ed to classical neurotransmitter-ffPA axis interaction but that it also involves opioid inhibitory mechanisms.
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Publisher Date 1983-01-01