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Author Findlay, Brian P. ♦ Fuchs, Charles S.
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Plasma Insulin-like Growth Factor Protein ♦ Metastatic Colorectal Cancer ♦ Baseline Plasma Level ♦ Insulin-like Growth Factor ♦ Combination Chemotherapy ♦ Plasma Sample ♦ Symptom Distress Scale ♦ Uniscale Instrument ♦ Noncancer Population ♦ Colorectal Cancer
Abstract Objective: Predictors of quality of life (QOL) in patients with metastatic colorectal cancer are lacking. The insulin-like growth factor (IGF) family of proteins is associated with QOL in noncancer populations. We sought to study whether these proteins are associated with QOL in patients with colorectal cancer. Method: We used a cohort of 526 patients with metastatic colorectal cancer treated with combination chemotherapy. Plasma samples of IGF-I, IGF-II, IGF binding protein-3, and C-peptide were collected before initiation of chemotherapy. QOL was measured by the uniscale instrument and the Symptom Distress Scale at baseline and throughout treatment. Results: Baseline plasma levels of IGF-I and IGF-II before
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study