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Author Strutz, Frank ♦ Müller, Gerhard A.
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Renal Fibroblast ♦ Translational Nephrology Renal Fibrosis ♦ Tubulointerstitial Fibrosis ♦ Renal Biopsy ♦ Resident Interstitial Fibroblast ♦ Extracellular Matrix Component ♦ Several Possibility ♦ Glomerular Change ♦ Collagen Type ♦ Matrix-producing Cell ♦ Progression Many Study ♦ Tubulointerstitial Involvement ♦ Nephrology Community ♦ Renal Prognosis ♦ Renal Function ♦ Important Implication ♦ Recent Year ♦ Tubulointerstitial Damage
Abstract transition; fibrosis; progression Many studies have determined that the extent of tubulointerstitial involvement, particularly fibrosis, correlates better with renal function than glomerular changes do, thus, the extent of tubulointerstitial damage in any given renal biopsy has important implications for the renal prognosis of the patient (summarized in [1]). Tubulointerstitial fibrosis is characterized by the accumulation of extracellular matrix components including collagen types I, III, IV, proteoglycans and fibronectin. In recent years, much controversy has been created in the nephrology community regarding the origin of matrix-producing cells in the kidney. Several possibilities exist, including activation of resident interstitial fibroblasts, migrating
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study