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Author Md, Ciro Casanova ♦ Md, Ro Sánchez ♦ Md, Ignacio Garcı́a-Talavera ♦ Pablo, Juan ♦ Md, Torres ♦ Md, Juan Abreu ♦ Manuel, Jose ♦ Md, Valencia ♦ Scm, O. Aguirre-Jaime ♦ Md, Bartolome ́ R. Celli
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Moderate Hypoxemia ♦ Copd Patient ♦ Daily Living ♦ Twenty-four-hour Ambulatory Oximetry Monitoring ♦ Chronic Obstructive Pulmonary Disease ♦ Stable Copd ♦ Big Difference ♦ Charlson Index ♦ Arterial Blood Sample ♦ Diurnal Desaturations ♦ Diurnal Time ♦ Oximetry-measured Blood Oxygen Sat-uration Spo2 ♦ Respiratory Questionnaire ♦ Vital Capacity ♦ Gas Exchange ♦ First Second Fev1 ♦ Following Variable ♦ Valuable Information ♦ Diurnal Desatura-tions ♦ Usual Activity ♦ Clinical Aspect ♦ Pulmonary Function ♦ Ambulatory Oximetry ♦ Important Desaturations ♦ Daytime Arterial Blood Gas Value ♦ Comprehensive Evaluation ♦ Body Mass Index ♦ Saint George ♦ Forced Expiratory Volume ♦ Mm Hg
Abstract BACKGROUND: The relationship of diurnal desaturations (oximetry-measured blood oxygen sat-uration [SpO2] < 90%) during activities of daily living and clinical aspects in patients with chronic obstructive pulmonary disease (COPD) and moderate hypoxemia has not been systematically eval-uated. METHODS: We prospectively studied 88 patients with stable COPD (forced expiratory volume in the first second [FEV1]< 80 % of predicted, ratio of FEV1 to forced vital capacity< 70% of predicted, and PaO2 60–70 mm Hg) with 24 hours of ambulatory oximetry. Desaturators were defined as those who spent> 30 % of the time with SpO2 < 90%. Patients engaged in their usual activities of daily living. We correlated these desaturations with the following variables, measured immediately before the 24 hours of oximetry: body mass index, dyspnea (measured with the mod-ified Medical Research Council dyspnea scale), gas exchange, pulmonary function, quality of life (measured with the Saint George’s respiratory questionnaire), and comorbidity (measured with the Charlson index). RESULTS: Thirty-three (38%) of the patients were desaturators: 50 % nocturnal and 22 % diurnal. We also measured daytime arterial blood gas values from arterial blood samples and found that the desaturators had higher PaCO2 (p 0.001) and lower PaO2 (p 0.007) than the nondesaturators. There were no differences in the other variables. The correlation between noc-turnal and diurnal time with SpO2 < 90 % was r 2 0.67, and the concordance was low (Cohen’s kappa 0.43, p < 0.001). CONCLUSIONS: Patients with stable COPD and moderate hypoxemia have frequent and potentially important desaturations during activities of daily living and at night. In addition, there is a big difference in the profile and degree of nocturnal and diurnal desatura-tions. Twenty-four hours of oximetry provides valuable information for comprehensive evaluation of patients with COPD. Key words: chronic obstructive pulmonary disease, COPD, ambulatory, oxim-
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study