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Author Fedder, Jens ♦ Gabrielsen, A. ♦ Humaidan, P. ♦ Erb, K. ♦ Ernst, E. ♦ Loft, A.
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Testicular Sperm ♦ Sex Ratio ♦ Malformation Rate ♦ Follow-up Study ♦ Icsi Child ♦ Conventional Ivf ♦ Male Offspring ♦ Extensive Use ♦ Increased Major Malfor-mation Rate ♦ Mal-formation Rate ♦ Danish Child ♦ Norway Follow-ing Icsi ♦ Remarkable Finding ♦ General Population ♦ Confidence Interval ♦ Immature Male Germ Cell ♦ Increased Frequency ♦ Methodological Limitation ♦ Major Malformation ♦ Response Rate ♦ Poten-tial Risk ♦ Natural Fertilization Process
Abstract BACKGROUND: Follow-up studies of children conceived after ICSI using epididymal or testicular sperm are import-ant due to a still more extensive use of immature male germ cells for ICSI. It is, however, difficult to evaluate the poten-tial risks of malformations of children born after ICSI, overcoming the natural fertilization processes, due to methodological limitations. METHODS: Follow-up study including all children born in Denmark and Norway follow-ing ICSI in Denmark, using epididymal or testicular sperm, was done. A questionnaire was sent to the parents between 3 months and 7 years after delivery. RESULTS: Of 341 couples, 329 returned the questionnaire giving a response rate of 96.5%. The study included 412 children, 225 girls and 187 boys, giving a sex ratio (males/males1 females) of 45.4% compared with 53.1 % in Danish children conceived after conventional IVF without ICSI (P < 0.005). Among a total of 14 (3.4%; 95 % confidence interval (CI): 1.9%–5.7%) major malformations, three boys with hypospadias were the most remarkable finding (1.6%; 95 % CI: 0.33–4.7%). CONCLUSIONS: An increased frequency of hypospadias in the male offsprings was seen compared with the general population. Apart from this, no increased major malfor-mation rate was detected in ICSI children conceived with epididymal or testicular sperm when compared with mal-formation rates for IVF or spontaneously conceived children reported in the literature. The sex ratio was significantly lower for ICSI children conceived with epididymal or testicular sperm when compared with children conceived with conventional IVF.
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study