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Author Pierce, Lori J.
Source CiteSeerX
Content type Text
File Format PDF
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword High Rate ♦ Lung Density Correction ♦ Multivariate Analysis ♦ Unit Density ♦ Breast Conservation ♦ Ductal Carcinoma ♦ Local Control ♦ Close Surgical Margin ♦ Predic-ted Cosmetic Outcome ♦ Whole Breast Radiation Therapy ♦ Patient Separation ♦ Whole Breast Radiotherapy ♦ Breast-conserving Treatment ♦ Excellent Cosmetic Result ♦ In-breast Failure ♦ Underwent Bcs ♦ Ajcc Stage ♦ 10-year Cumulative Rate ♦ Key Word ♦ Median Total Follow-up ♦ Localized Ductal Carcinoma ♦ First Study ♦ Treatment Outcome ♦ Breast-conser-ving Surgery ♦ Breast Cancer ♦ Cosmetic Outcome ♦ Family History ♦ Assessed Patient ♦ Local Failure
Description n Abstract: The purpose of the study was to review the treatment outcomes of 198 patients treated with breast-conser-ving surgery (BCS) and whole breast radiation therapy using lung density correction for ductal carcinoma in situ (DCIS). Between April 1985 and December 2002, 198 patients with 200 lesions diagnosed as DCIS (AJCC stage 0) were treated at the University of Michigan. All underwent BCS and whole breast radiotherapy. Median total follow-up was 6.2 years (range: 0.8–18.2). The 5- and 10-year cumulative rates of in-breast only failure were 5.9 % (95 % CI: 2.6–9.3%) and 9.8 % (95 % CI: 5.2–14.4%), respectively. Factors that significantly predicted for an increased risk of local failure were family history of breast cancer, positive or close surgical margins and age £ 50 years at diagnosis. Cosmetic outcome was scored as ‘‘excellent’ ’ or ‘‘good’ ’ in 94 % of the assessed patients. On multivariate analysis, only patient separation significantly predic-ted cosmetic outcome (p = 0.04). BCS and radiotherapy using lung density correction resulted in high rates of local control at 5 and 10 years with excellent cosmetic results. To the best of our knowledge, this is the first study to report outcome in a series of patients with DCIS treated with lung density correction and results compare favorably with other series in which plans were calculated using unit density. n Key Words: breast conservation, DCIS, lung density correction, radiotherapy Breast-conserving treatment has become the stand-ard of care for localized ductal carcinoma in situ (DCIS) of the breast (1). Lumpectomy followed by
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 1985-01-01
Publisher Institution in Software Reliability," NASA Contractor Report 172553