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Author Naseri, Mitra ♦ Madani, Abbas ♦ Ataei, Neamatollah
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Focal Segmental Glumerulosclerosis ♦ Renal Failure ♦ Cyclosporine Resistant Patient ♦ Normal Renal Function ♦ Biopsy Proven Idiopathic Fsgs ♦ Prognostic Value ♦ Poor Prognosis ♦ Protective Factor ♦ Immune System ♦ Idiopathic Nephrotic Syndrome ♦ Relative Risk ♦ Stage Renal Disease ♦ Similar Study ♦ Steroid Resistant Patient ♦ Evidence Support Disease Relationship ♦ Historical Cohort ♦ Cyclophosphamide Responsive Patient ♦ Study Design ♦ Dis-ease Progression ♦ Definite Conclusion ♦ Favorable Response ♦ Steroid Re-sponsive Patient ♦ Focal Segmental Glo-merulo-sclerosis ♦ Cyclophosphamide Resistant Patient ♦ End-stage Renal Disease
Abstract Abstract- To determine the prognostic value of response to treatment in patients with focal segmental glo-merulo-sclerosis. FSGS includes 10-15 % of idiopathic Nephrotic syndrome in children. Bulk of evidence supports disease relationship with immune system. Unfortunately, responses to immunosuppressive drugs are not desirable and progression to end-stage renal disease is common. We analyzed 62 out of 99 cases of biopsy proven idiopathic FSGS who were followed for at least 5-years or until renal failure occurred during study. Study design was historical cohort and patients were divided into two groups: exposed (resistant to treatment) and non-exposed (responsive to treatment). Correlation between prognosis and response to treatment was sta-tistically evaluated. P-value (0.05 and relative risk ( 1 was considered significant. In 3 out of 25 steroid re-sponsive patients (12%) and 22 out of 37 steroid resistant patients (59.5%), disease progressed to renal fail-ure. Disease progressed to renal failure in 2 out of 11 cyclophosphamide responsive patients (18.1%), 17 out of 23 cyclophosphamide resistant patients (74.3%), and 8 out of 14 cyclosporine resistant patients (57.1%). 2 patients who responded to cyclosporine had normal renal function at the time of the last follow up. We con-cluded that favorable response to steroid and cyclophosphamide treatment is a protective factor against dis-ease progression to end stage renal disease and resistance to these drugs imply a poor prognosis. For making any definite conclusion concerning response to cyclosporine treatment and prognosis, similar studies with a
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article