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Author Guenegou, Armelle ♦ Boczkowski, Jorge ♦ Aubier, Michel ♦ Neukirch, Francxoise
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword European Community Respiratory Health Survey ♦ Serum B-carotene Level ♦ L-allele Carrier ♦ 8-year Lung Function Decline ♦ General Population ♦ Heme Oxygenase-1 Gene Promoter Polymorphism ♦ Original Contribution Interaction ♦ Confidence Interval ♦ Fev1 Decline ♦ Impaired Lung Function ♦ Pulmonary Disease ♦ Major Role ♦ Lung Function De-cline ♦ Antioxidant Response ♦ General Population Sample ♦ High Serum Level ♦ Low B-carotene Level ♦ Powerful Antioxidant Enzyme Heme Oxygenase-1 ♦ Accelerated Decline ♦ Heme Oxygenase-1 ♦ Annual Decline ♦ Baseline Age ♦ Ml Year ♦ Beta Carotene ♦ French Subject ♦ Body Mass Index ♦ Gt Repeat ♦ High Level ♦ Steeper Mean Fev1 Decline ♦ Forced Expiratory Volume ♦ Follow-up Study ♦ Oxidative Stress ♦ Chronic Obstructive Pulmonary Disease ♦ Large Number ♦ High B-carotene Level
Abstract Oxidative stress is thought to play a major role in the pathogenesis of chronic obstructive pulmonary disease, characterized by impaired lung function. A large number (33) of GT repeats (L-allele) in the gene of the powerful antioxidant enzyme heme oxygenase-1 has been associated with susceptibility to accelerated lung function de-cline. In contrast, b-carotene may help to protect against accelerated decline. To determine whether high serum levels of b-carotene might counterbalance the greater susceptibility of L-allele carriers, the authors analyzed the annual decline in forced expiratory volume in 1 second (FEV1) in a general population sample of 523 French subjects (20–44 years, 50 % men) examined in 1992 and 2000 as part of the European Community Respiratory Health Survey. Analysis of covariance, adjusted for sex as well as baseline age, body mass index, smoking, and FEV1, showed that, among subjects with low b-carotene levels, L-allele carriers experienced a steeper mean FEV1 decline than did noncarriers (mean 58.8, 95 % confidence interval: 73.2, 44.5 vs. mean 34.7, 95% confidence interval: 38.9, 29.8 ml/year) (p 0.009), whereas among subjects with high b-carotene levels, the FEV1 decline was not different in L-allele carriers and noncarriers (two-sided p 0.9). The results suggest that high levels of b-carotene might counterbalance the effects on FEV1 decline of a genetically determined deficiency in antioxidant response. beta carotene; follow-up studies; France; heme oxygenase-1; polymorphism, genetic; pulmonary disease, chronic
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Publisher Date 2007-01-01