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Author Lee, Ok-Jae ♦ Regine Schneider-Stock, Z. ♦ Mcchesney, Patricia A. ♦ Doerthe Kuester, Z. ♦ Albert Roessner, Z. ♦ Vieth, Michael ♦ Christopher A. Moskaluk, B.
Source CiteSeerX
Content type Text
File Format PDF
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Tumor Sample ♦ Protein Expression ♦ Known Risk Factor ♦ Epigenetic Mechanism ♦ Barrett Carcinogenesis ♦ Gpx3 Mrna ♦ Oxidative Mucosal Damage ♦ Barrett Metaplasia ♦ Glutathione Peroxidase-3 ♦ Barrett Esophagus ♦ Promoter Hypermethylation ♦ Barrett Tumorigenesis ♦ Chronic Gastroesophageal Reflux Disease ♦ Potent Extracellular Antioxidant Activity ♦ Barrett Adenocarcinoma ♦ Secretory Protein ♦ Gpx3 Promoter Hypermethylation ♦ Gpx3 Gene Inactivation
Description Chronic gastroesophageal reflux disease is a known risk factor for Barrett’s esophagus (BE), that induces oxidative mucosal damage. Glutathione peroxidase-3 (GPx3) is a secretory protein with potent extracellular antioxidant activity. Herein, we have investigated the mRNA and protein expression of GPx3, and explored promoter hypermethylation as an epigenetic mechanism for GPx3 gene inactivation during Barrett’s carcinogenesis. Quantitative real-time reverse transcription polymerase chain reaction on 42 Barrett’s adenocarcinomas (BAs) revealed consistently reduced levels of GPx3 mRNA in 91 % of tumor samples. GPx3 promoter hypermethylation was detected in 62 % of Barrett’s metaplasia, 82 % of dysplasia, and 88 % of BA
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Institution Cancer Res 2007; 67: (17). September 1, 2007 8050 www.aacrjournals.org Downloaded from cancerres.aacrjournals.org on February 21, 2013 Copyright © 2007 American Association for Cancer Research