Access Restriction

Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Tumor Angiogenesis ♦ Polymer-peptide Conjugate ♦ Endothelial Cell ♦ Xenograft Model ♦ Tissue Biodistribu-tion ♦ Enhanced Vascular Permeability ♦ Molecular Size ♦ Blood Clearance ♦ Macromolecular Peptide-copolymer Conjugate ♦ Present Unique Molecular Marker ♦ Nonspecific Peptide ♦ Targeted Therapy ♦ Nonspecific Vascular Permeability ♦ Side Chain ♦ Disordered Lymphatics ♦ Relative Importance ♦ Tumor-to-normal Tissue Background Ratio ♦ Prostate Cancer ♦ Local-izing Angiogenesis-targeted Agent
Abstract Endothelial cells in tumor angiogenesis are highly accessible, genetically stable and present unique molecular markers for targeted therapy. Neoplasia is also characterized by enhanced vascular permeability and disordered lymphatics so that both active and passive targeting strategies may play a role in local-izing angiogenesis-targeted agents. To investigate the relative importance of these targeting strategies, the tissue biodistribu-tion of both endothelial-specific and nonspecific peptides and their macromolecular peptide-copolymer conjugates were stud-ied in 2 xenograft models of prostate cancer. Tumor-to-normal tissue background ratios (T/B) of these constructs were com-pared to evaluate the effect of molecular size on blood clearance and nonspecific vascular permeability. Methods: Water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) co-polymers were synthesized with side chains terminated in a
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study