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Author Liaoa, Ben-Yang ♦ Wenga, Meng-Pin ♦ Zhangb, Jianzhi
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Physiological Evolution ♦ Contrasting Genetic Path ♦ Phenotypic Evolution ♦ Gene Gain Loss ♦ Expression Profile ♦ Central Topic ♦ Genetic Mechanism ♦ Protein Function Change ♦ Mouse Gene ♦ Affectingmorpho-logical Trait ♦ Protein Sequence ♦ Physiological Change ♦ Differential Molecular Basis ♦ Recorded Mutant Phenotype ♦ Gene Expres-sion Change ♦ Evolutionary Biology ♦ Transcriptional Regulator ♦ Likely Tobetissuespecific ♦ Relative Importance ♦ Physiological Trait
Abstract The relative importance of protein function change and gene expres-sion change in phenotypic evolution is a contentious, yet central topic in evolutionary biology. Analyzing 5,199 mouse genes with recorded mutant phenotypes,wefind that genes exclusively affectingmorpho-logical traits when mutated (dubbed “morphogenes”) are grossly enriched with transcriptional regulators, whereas those exclusively affecting physiological traits (dubbed “physiogenes”) are enriched with channels, transporters, receptors, and enzymes. Compared to physiogenes, morphogenes are more likely to be essential and pleio-tropicand less likely tobetissuespecific.Morphogenesevolvefaster in expression profile, but slower in protein sequence and gene gain/loss than physiogenes. Thus, morphological and physiological changes have a differential molecular basis; separating them helps discern the genetic mechanisms of phenotypic evolution. evolutionary rate gene expression molecular evolution phenotypic
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study